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Original Articles Open Access
In the present investigation, an attempt is made to develop and characterize floating tablets of ranitidine hydrochloride to increase the safety of the drug and to extend its duration of action for patient compliance. Floating tablets of ranitidine hydrochloride were prepared using HPMC K4 M, Sodium CMC and Guar gum as control release polymers in different concentration with citric acid and sodium bicarbonate as a gas generating agent by direct compression method. The prepared formulations were evaluated for pre and post compression parameters such as angle of repose, bulk density etc. and weight variation, hardness, friability, drug content uniformity, floating lag time, total floating time, in-vitro drug release etc. Respectively. Out of fifteen formulations, formulation GTH1 was selected as promising formulation. The In-vitro drug release, floating lag time and floating time of GTH1 were found to be 97.36±4.6%, 10 mins and >12 hrs respectively. The different formulations of Ranitidine hydrochloride can be prepared by using HPMC K4M, Sodium CMC and Guar gum. The prepared formulations were shown good floating time, extended release and physical stability.
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Author(s): D Nagendrakumar Keshavshetti G G and Bhagyashri Patil
Ranitidine hydrochloride, HPMC K4M, Sodium CMC, Guar gum and Carbopol