alexa Abstract | Enhanced Suspension Stability : Choice Of Crystal Habit

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access


It is well established that the polymorphic state of a solid can modify physicochemical properties and suspension stability of drugs. However, not much attention has been paid towards crystal habit, the other seemingly trivial property of a crystalline solid. This study reveals that different habits of sulphamethoxazole belonging to the same polymorphic state can be obtained by varying the crystallization conditions, normally associated with preparation of different polymorphs. This implies that the same polymorphic form can exist in different habits. The selected habits were found to differ significantly with respect to shape parameters, bulk density and dissolution rate. The suspension formulations containing these habits exhibited significantly different physical stability than that formulated with the parent drug material. However, due to insignificant difference in ΔH1,value of the crystals and inherent nature to be rapidly absorbeds the Ka,Tmax and extent of free as well as acetylated sulphamethoxazole excreted were not significantly altered.

To read the full article Peer-reviewed Article PDF image

Author(s): A K Tiwary G M Panpalia

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version