alexa Abstract | Enhanced Transdermal Permeation Of Bupropion Hydrochloride By Chemical Modification

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access

Abstract

Bupropion, a monocyclic aminoketone is used primarily for the treatment of major depression. On oral administration, the drug undergoes extensive first pass metabolism. Delivery of bupropion via transdermal route would minimize some of the deficiencies associated with the oral delivery. In the present study, effect of various vehicles and penetration enhancers on diffusion kinetics of the salt and free drug through the human cadaver skin was studied using a modified diffusion cell. The diffused drug was quantified by UV spectrophotometry at 298 nm in phosphate buffer saline. A 100-fold increase In permeability rate was observed with free base compared to salt form. As a vehicle, alcohol was found to be superior compared to phosphate buffer saline and propylene glycol in permeation of free base. Permeation was enhanced by up to 30 %with linseed oil and myristic acid when propylene glycol was used as a vehicle. The study provides suitable clues for delivery of bupropion by the transdermal route.

To read the full article Peer-reviewed Article PDF image

Author(s): DP Gondaliya K Pundarikakshudu

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords