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Research Paper Open Access
Verapamil free base and diltiazem free base, were prepared from corresponding salt forms and characterized prior to evaluate their in vitro diffusion kinetics from ethylenevinylacetate-vinylacetate 40% copolymer membrane. Base forms of original drug molecules exhibited enhanced trans membrane permeation as compared to corresponding salt forms; facilitating to deliver the drug in a controlled manner, across a convenient small surface area of delivery device.
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Author(s): Y K Agrawal H M Tank