alexa Abstract | Enzymatic Pathways of Intracellular Survival, Replication and Phagosomal Escape of Francisella spp.: A Review

Molecular Enzymology and Drug Targets
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Review Article Open Access

Abstract

Francisella tularensis is an important microbial agent which causes the severe infection of tularemia. The intracellular life cycle of this bacterium is supported by a vast range of protective guards such as enzymes. Although several enzymes are recognized in different subspecies of the bacterium, acid phosphatase and superoxide dismutase are seen in all bacterial subspecies. On the other hand, the most important enzymatic system relating to host cells is NADPH oxidase. For this reason, the clear aim of this mini-review is to discuss about the intracellular life cycle of Francisella tularensis and important enzymatic machineries in association to bacterium and its host cells. As a result, all of the biological systems including bacterial (prokaryotic) and host (eukaryotic) cells are protected by their enzymatic machineries. There are a wide range of enzymes within organisms. But, NADPH oxidase (in host cells), acid phosphatase and superoxide dismutase (in all of Francisella tularensis subspecies) were the main enzymes in this discussion. In conclusion, detection and identification of the enzymatic machineries and their activities enables us to find out appropriate mechanisms for definite therapeutic methods.

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Author(s): Payam Behzadi Reza Ranjbar

Keywords

Francisella tularensis, Phagocyte, Enzyme, Enzymes and Drug Targets, Enzymes and Drug Targets, Molecular Enzymology

 
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