alexa Abstract | Establishment of a virtual molecule fragment library for non-steroidal aromatase inhibitors

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Breast cancer is a common and frequently-occurring disease which has serious impact on women's health and life. Aromatase inhibitors play an important role in endocrine treatment of breast cancer. It is necessary to find new aromatase inhibitors for the improvement of the treatment efficacy and the reduction of drug resistance and side effects. In this paper,490 molecules in Binding DB with the top aromatase activities (the lowest IC50 for aromatase inhibition) were disassembled into a few basic pieces to build molecular common structural fragment libraries of aromatase inhibitors using the RECAP analysis function module in MOE 2013 software. This library can provide basic molecular structural source materials for the new drug design of aromatase inhibitors.

To read the full article Peer-reviewed Article PDF image

Author(s): Dai Yujie Sun Ziyue Liu Shaodan Cui Qingxin Zhang Tongcun and Zhang Xiuli

Keywords

Aromatase inhibitors, virtual molecule fragment library, RECAP analysis,MOE software,IC50, non-steroidal aromatase inhibitors

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords