alexa Abstract | Estimated rates of treatment failure in first-line antiretroviral treatment in Kinshasa: Case of the ACS AMO-Congo

International Journal of Collaborative Research on Internal Medicine & Public Health
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Introduction: In the Democratic Republic of Congo (DRC), the first line of treatment for HIV adopted since 2008 for the PLHIV is a combination of single-dose Azydothimidine (AZT), Lamivudine (3TC) and Nevirapine (NVP). In 2009, 34 947 PLHIV were on the first line HAART in the DRC, of which 28,918 or 82.75% were adults.

Objective: Estimate the rate of treatment failure in first-line antiretroviral therapy in treatment centers in Kinshasa.

Method: This study is a cross-sectional study in three outpatient treatment centers of the NGO ACS AMO-Congo in the city of Kinshasa in the Democratic Republic of Congo in January 2009. Any patient on antiretroviral therapy in first intension followed regularly in one of three centers of study for more than six months in January 2009 was considered. Blood sampling was done in a tube with EDTA anticoagulant, from a venous puncture. The numbering of CD4 has been made in the laboratory of ACS / AMO-Congo Kasa Vubu on FACSCountTM and viral load at the National Reference Laboratory AIDS / STI (LNRS) by NucliSens Easy Q - HIV1, Version 1, 2. Data were entered using Excel and SPSS software. The Student test was used for quantitative variables and Chi-square (X2) for categorical variables. The significance (p) was chosen for the probability of p <0.05. Results are expressed as mean ± standard deviation. The tables have been reformatted in Excel. Respect for the individual and the confidentiality of records were found.

Result: A total of 102 patients were included in this work with a female predominance (66.7%) and a mean age of 41.4 ± 9.4 years. The mean CD4 count of third control (395.5 ± 145.2 cells / l) were significantly higher than those of CD4 at baseline (252.1 ± 128.7 cells / l). Controls were performed CD4 at 1 month (control 1), 3 months (control 2) and ± 6 months (control 3). The viral load (VL) average of 20,258.3 ± 10,209.0 RNA copies / ml. Eighteen patients (17.6%) had a CD4 count lower than the third control values before treatment, 16 patients (15.7%) had a viral load above 1000 RNA copies / ml and 7 patients (6.9%) evolved at the AIDS stage.

Conclusion: The estimated rate of treatment failure of patients on ARV first line in Kinshasa conducted in 3 treatment centers for AMO-Congo gave a rate of 17.6%.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): KAMANGU NTAMBWE ERICK KAWILA MAFANDA EUPHRASIE MUKUMBI HENRI MVUMBI LELO GEORGES

Keywords

HIV treatment failure, viral load, CD4

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords