alexa Abstract | Estimation of tegaserod maleate by differential pulse polarography

Indian Journal of Pharmaceutical Sciences
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Abstract

A highly sensitive differential pulse polarographic method has been developed for the estimation of tegaserod maleate after treating it with hydrogen peroxide solution. The oxidation of tegaserod maleate is a reversible process as the oxidized product could be reduced at hanging mercury drop electrode in a quantitative manner using differential pulse polarography mode. The limit of quantification was 0.1ng/ml. The voltametric peak was obtained at -1.05 volts in presence of 0.1M potassium chloride as supporting electrolyte. The technique could be used successfully to analyze tegaserod maleate in its tablet formulation.

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Author(s): SJ Rajput HA Raj

Keywords

Differential pulse polarography, hanging mercury drop electrode

 
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