alexa Abstract | Estudio comparativo de la eficacia de los fármacos anticolinesterésicos en la función cognitiva de pacientes con Enfermedad de Alzheimer

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Abstract

El objetivo de este estudio es comparar la eficacia sobre el rendimiento cognitivo delos distintos fármacos anticolinesterásicos aprobados actualmente para laEnfermedad de Alzheimer (donepezilo, rivastigmina y galantamina). Para ello se hacalculado de forma retrospectiva para cada paciente un índice que representa lavariación media mensual en la puntuación del MMSE (VMM-MMSE) y que se obtienedividiendo la variación total de puntuación en el MMSE en todo el periodo evaluadopara cada paciente entre el número de meses de seguimiento. El análisis estadísticoque compara los VMM-MMSE de cada fármaco demuestra que no existen diferenciassignificativas en la eficacia sobre el rendimiento cognitivo entre los distintosfármacos anticolinesterásicos.

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Author(s): Marta Martnez Rivera Manuel Mnendez Gonzlez

 
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