alexa Abstract | Evaluation acute toxicity and antibacterial activity of Penicillium sp Nendophitic fungus extract of kunyit putih (Curcuma zedoaria) in mice (Mus musculus L.)

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Evaluation acute toxicity and antibacterial activity of Penicillium sp endophitic fungus extract of kunyit putih (Curcuma zedoaria) in mice (Mus musculus L.) had been done. Acute toxicity at concentration until 2000 mg/kg BW and anticahterial test was done used S. dysentriae bacteria by giving 6 treatments contain treatment I (normal control), treatment II (negative control), treatment III (dose I 125 mg/kg BW), treatment IV (dose 250 mg/kg BW), treatment V (dose 500 mg/kgBB), and treatment VI ( positive control ciprofloxacin dose 10 mg/kg BW). Observation was done based on amount of S. dycentriae bacteria in faeces taken once in 2 days along 12 days. Bacteria population data on the mice faeces analyzed by statistical analysis. At acute toxicity no mortality was observed at 2000 mg/kg BW for 24 h observation. Observed for toxic symptoms such as behavioural change, locomotion convulsion was not found. The experiment antibachterial activity result that treatment III to VI show the population of Shigella which is not different. Effect treatment time to population of bacteria shows in the 10 and 12 the bacteria amount fall below infection dose (2,40 x 105 and 6,76 x 104 ) respectively, thus can be concluded that the extract had acted as a cure.

To read the full article Peer-reviewed Article PDF image

Author(s): Muharni Heni Yohandini Fitryab and Roni

Keywords

Endophytic fungus, Penicillium sp, Curcuma zedoaria, acute toxicity, antibacterial, Nendophitic fungus

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords