alexa Abstract | Evaluation of Alkaline phosphatase (ALP) and Heat Stable- ALP (HS-ALP) in Chronic Obstructive Pulmonary Disease (COPD)

International Journal of Collaborative Research on Internal Medicine & Public Health
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Background: COPD (Chronic Obstructive Pulmonary Disease) is defined as a disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually both progressive and associated with an abnormal inflammatory response of the lungs to noxious particles and gases. Tobacco smoke remains the main etiological agent. COPD inflammation initiated by tobacco smoke remains exuberant long after smoking cessation. Functional impairment of lung organ is reflected by impairment in FEV1% predicted. This is the result of underlying remodeling and fibrosis in small airways. Type 2 alveolar cells are involved in this process of remodeling and repair. Many of the studies have showed that heat stable alkaline phosphatase (HS-ALP) is released from these type 2 alveolar cells.

Objectives: To correlate serum activity of ALP, HS-ALP, FEV1% predicted and BMI in various stages of COPD patients.

Method: This study tried to evaluate correlation between serum activity of ALP, HS-ALP and FEV1% predicted and BMI in various stages of COPD. Total 45 patients of stage 2, 3, 4 of COPD were studied. Result: We found there is unanimous increase in total ALP activity in all the stages of COPD. HS- ALP is increased in all the stages of COPD with no difference in between the stages. There is no relation between ALP and HS-ALP and between FEV1% predicted and BMI. We find that HS-ALP once considered as carcino-embryonic antigen is increased in lung inflammation of COPD.

Conclusion: Serum ALP and HS-ALP which can be very easily measured could be the one of the laboratory marker for diagnostic and prognostication of COPD patients.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Anup N Nillawar Jayashree S Bardapurkar Suhas J Bardapurkar

Keywords

COPD, ALP, Heat stable-ALP

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords