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Therapeutic angiogenesis is the method of stimulation of angiogenesis where it is required but lacking. It represents an excellent tool for the treatment of deregulated angiogenesis based cardiovascular diseases. It is a potent physiological process that underlies the natural manner in which our bodies respond to a diminution of blood supply to vital organs, namely the production of new collateral vessels to overcome the ischemic state. This present study is aimed to evaluate and quantify the Angiogenic potential of Terminalia Bellirica Roxb, belonging to the family of Combretaceae. Angiogenic activity of Ethanolic extract of Terminalia bellirica leaf by CAM assay was determined, after 14 days of incubation, strongly elicited on angiogenic response, which is visible with the microscope as a spoke-wheel-like pattern of blood vessels. However, around the control gelatin sponge containing vehicle alone, less growth of new blood vessels was observed, Application of 300 :g of EETB exhibits 73.33% of positive response. The angiogenesis index in the chick CAM was increased in the dose dependent manner. The Phytochemical screening and qualitative instrumental analysis was done which reveals the presence of proteins and Phytosterols exhibits strong angiogenic actions and also may have the potential to be a useful activator of the large number of serious diseases characterized by deregulated angiogenesis. It was observed that EETB significantly promotes the development of capillary networks in CAM and these newly synthesized vessels participated actively in the circulating of blood cells in-ova. Further study is required to define more precisely the molecular mechanisms by which EETB modulates endothelial cell function and gene expression as well as the pathological relevance of these findings.

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Author(s): V Vinoth Prabhu VGopal


Angiogenic growth factors, Sponge implantation assay, Terminalia bellirica, Therapeutic angiogenesis

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