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The aim of present study was to investigate antiepileptic activity of the Aqueous and Methanolic extracts of the fruit pericarp of Sapindus mukorossi on electrically and chemically induced seizures. The latency of tonic convulsions and the number of animals protected from tonic convulsions were noted. Both the extracts of Sapindus mukorossi in the Maximal Electric Shock (MES) study were not able to abolish tonic hind limb extension but significantly reduced its duration. Phenytoin and Diazepam used as references in this experiment caused significant reduction of the tonic hind limb extension phase and completely abolished this behavior. In PTZ study, both the extracts of Sapindus mukorossi caused significant dose-dependent anticonvulsant effect against PTZ-induced seizures by delaying the onset of myoclonic jerks and tonic convulsions in rats. It also caused profound decrease in the duration of the tonic convulsions. Diazepam and Phenytoin sodium which was used in this study as a reference anticonvulsant agent showed significant activity by delaying the onset of myoclonic jerks and tonic convulsions and decreasing the frequency and duration of tonic convulsions. In conclusion this work suggests that extract of fruits of Sapindus mukarossi possess antiepileptic properties that may be due to restoring the neurochemical substances in rat brain. These results support the ethno medical uses of the plant in the treatment of epilepsy. However more experimentation and experimental analysis are required for a definitive conclusion.
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Author(s): Anitha K Jyothi Y Vamsee Veena A and Deepika Bora
Anti epileptic activity, Phenytoin, Diazepam, Tonic hind limb extension, Myoclonic jerks