alexa Abstract | Evaluation Of Antiinflammatory And Antihyperalgesic Activity Of Some Novel Monocylic β-Iactam Compounds In Rats.

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Synthesis and evaluation of some novel monocyclic beta-lactam compounds as anti-inflammatory and anti-hyperalgesic agents has been carried out in the present study. Such type of compounds has been reported in literature as human leukocyte elastase (HLE) inhibitors. The compounds were administered orally (15 mg/kg) to rats 30 min before injecting carageenan in the planter aponeurosis. The compounds showed a marked effect on paw edema and associated inflammatory pain. Compound 1 showed antiinflammatory effect even better than indomethacin (10 mg/kg) used as reference standard. These results suggest the need of carrying out further in vitro studies on the mechanism of action, which may be HLE inhibition.

To read the full article Peer-reviewed Article PDF image

Author(s): R K Goel Amanpreet Singh M P Mahajan S K Kulkarni

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords