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The present study investigates the antiinflammatory activity of ethanolic and aqueous extracts of Curcuma zedoaria Rosc roots in albino rats by using Carrageenan and Histamine induced hind paw edema method. The medicinal values of Curcuma zedoaria root have been mentioned in ancient literature as useful in disorders of inflammation. Dried pulverized root of Curcuma zedoaria was extracted with ethanol by using soxhlet apparatus and aqueous extract was prepared by cold maceration. The paw edema was induced by subplantar injection of above inflammagens and oedema volume was recorded using a Plethysmometer. Ethanol 200 and 400 mg/kg root extracts showed significant p<0.001 anti-inflammatory activity on 2nd to 6th hours and aqueous root extract showed non-significant antiinflammatory activity when compared with control group using standard groups (Indomethacin 10 mg/kg.i.p and Rumalaya forte 200 mg/kg p.o). It concludes that ethanolic root extract of Curcuma zedoaria Rosc augments that it shows good antiinflammatory activity against carrageenan and histamine induced paw edema in rats.
Curcuma zedoaria Rosc, Carrageenan, Histamine, Anti-inflammatory.