alexa Abstract | Evaluation of antimicrobial and cytotoxic potential of Argemone mexicana L.

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

This study is an experimental in vitro research, aimed to evaluate antimicrobial potential and cytotoxicity of plant species Argemone mexicana L. (Papaveraceae) with a treatment of infected wounds perspective. Crude ethanolic extract was obtained after the solution concentration in a rotary evaporator and submitted to a fractionation by classical liquid chromatography column, resulting in four fractions: hexane, chloroform, ethyl acetate and methanol. A phytochemical screening was performed in crude ethanolic extract. Antibacterial activity was determined by the Minimum Inhibitory Concentration (MIC), where fractions were tested against major infectioncausing bacteria in wound and to evaluate the samples cytotoxicity was conducted the MTT (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay. In the studied samples, it was observed the presence of steroids, coumarins, anthrones and alkaloids, which is the majority metabolite. The cytotoxicity of the samples was observed at concentrations of 1000 μg and 100 μg. Among these, chloroform fraction at a concentration of 1000 μg and methanol fraction at a concentration of 100 μg showed no cytotoxicity with cell viability of 87 % and 90, 2 %, respectively. The antibacterial activity was observed in fractions against S. epidermidis and in methanol fraction front S. aureus, which showed a MIC of 166,66 μg/mL. This study may be useful to guide new investigations, depth and systematic, about the chemical compounds of this species and serves as subsidies for further herbal medicine development with perspective in treatment of infected wound.

To read the full article Peer-reviewed Article PDF image

Author(s): Araujo M G S Silva A L L SilvaJunior E F Santos Junior P F S Santos M S Bernardo T H L Bastos M L A AlexandreMoreira M S ArajoJnior J X and Verssimo R C S S

Keywords

Argemone mexicana, Medicinal plants, Nursing, Antimicrobials., Argemone mexicana L

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords