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Research Article Open Access
Acne vulgaris is the most common dermatological disorder among the individuals. The Propionibacterium acnes play a vital role in pathogenesis of acne inflammation. The P. acnes release neutrophill chemotactic factors which attracts polymorphonulcear leukocytes at site of infection. A Polymorphonulcear leukocyte induces the reactive oxygen species to create an oxidative stress which is responsible for acne inflammation. Conventional medical treatment has its own side effects besides the high cost. Ehanobotnical search reveals use of many traditional herbs in treatment of acne, which are usually free from side effects, are economical and also accessible to humans. Rubia cordifolia a well known plant traditionally being used as medicine in various skin disorders. It was thus thought worthwhile to evaluate antibacterial activity against Propionibacterium acnes by broth dilution and cup plate diffusion method. R. cordifolia extracts were also evaluated for antioxidant and lipid peroxidation inhibitory activity by 1, 1- diphenyl-2-picryl-hydrazyl and TBARs Thiobarbituric acid reactive substances method respectively. The study throws light on use of R. cordifolia in prevention and treatment of acne.
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Author(s): Archana M Gorle Swati S Patil
Rubia cordifolia, Propionibacterium acnes, reactive oxygen species, oxidative stress, lipid peroxidation, free radical scavengers.