alexa Abstract | Evaluation Of Commercial And Formulated Oral Rehydration Products

Indian Journal of Pharmaceutical Sciences
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Four million children die annually due to diarrhoea and many others causes that are aggravated by diarrhoea. An attempt was made to adopt Rice based Oral Rehydration Therapy (ORT) with a formulation of Rice. Oral Rehydration Salts (ORS) in tablet form. Commercially available ORS products are not in accordance with WHO-ORS formula, a wide variation in composition was observed. Analysis of marketed ORS reveals that the active constituents are within the label claim. Finally, the analysis of formulated Rice based ORS tablet revels that the Sodium ion (Na+) concentration, which causes hypernatremia in children, was less i.e., 60 mM from that of WHO formula of 90mM. This rice based ORS avoids the risk of hypernatremia and also reduced the stool volume and intensity of diarrhoea.

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Author(s): G Amar Krishna B G Nagavi

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