alexa Abstract | Evaluation of Complexed Starch-Urea-Citrate as A Novel Super Disintegrant

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The present investigation deals with the synthesis of starch-urea-citrate complex polymer by gelatinizing starch slurry with urea and citric acid. The formed starch-urea-citrate (SUC) polymer was found to be colorless and free flowing powder. Fast disintegrating tablets of ofloxacin were prepared using different concentrations of starch-urea-citrate (7.5-30% w/w of tablet) and evaluated for both pre and post compression studies. The results of granular micromeritic properties like bulk density, angle of repose, Carr’s index and hausner’s ratio showed that all the formulations possessed good flow properties, uniformity and compressibility. The complexation of SUC synthesis and also the compatibility between ofloxacin and the polymer were confirmed by IR spectroscopy. The compressed tablets showed good hardness (3.5-4kg/cm2) and friability values < 0.5% with uniformity in drug content within the range of 99.2 to 100.2 %. The disintegration time of all the formulations was less than one minute. From the results, it was observed that with increments in starch-urea-citrate concentration in the formulations, there was a decrease in the values of wetting time and the disintegration time. The optimized formulation showed a complete in-vitro drug release within 40 min. as compared to the commercial product. Thus it was made evident that the starch-urea-citrate could be used as an excellent super disintegrant.

To read the full article Peer-reviewed Article PDF image

Author(s): S Bharath Raghavendra Naik BV Basavaraj R Deveswaran V Madhavan


Oro-dispersible tablets, Starch-Urea-Citrate, Ofloxacin, Super disintegrant

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version