alexa Abstract | Evaluation of ethanol and aqueous extracts of cinnamomum verum leaf galls for potential antioxidant and analgesic activity

Indian Journal of Pharmaceutical Sciences
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Abstract

In the present study, ethanol and aqueous extracts of leaf galls of Cinnamomum verum were prepared to evaluate the antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay and superoxide radical scavenging assay with ascorbic acid as a standard, and analgesic activity by tail immersion test and acetic acid-induced writhing test methods using diclofenac sodium as the reference drug. Swiss albino mice maintained under standard laboratory conditions were used for analgesic tests. In the 2,2-diphenyl-1-picrylhydrazyl assay it was found that the aqueous and the ethanol extract possessed almost equal capacity to inhibit free radicals (IC 50 =13.3 and 13.53 µg/ml) but found less than ascorbic acid (IC 50 =9.96 µg/ml). And in superoxide assay the ethanol extract was found to be more potent in scavenging super oxide radicals when compared to ascorbic acid and the aqueous extract (IC 50 =237.1 and 197.8 µg/ml) with the IC 50 =119.7 µg/ml. For analgesic activity, ethanol extract showed the maximum time required for response against thermal stimuli (6.75±0.47 s) and maximum % of writhing inhibition (44.57%) when compared to aqueous extract (5.25±0.48 s and 32.61%), whereas diclofenac showed response in 7.25±0.25 s 67.39% inhibition in tail immersion and writhing tests, respectively. These results demonstrate that the ethanol extracts of leaf galls possessed high antioxidant and analgesic activity.

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Author(s): Minakshi Pandey DR Chandra

Keywords

Cinnamomum verum , antioxidant activity, analgesic activity, DPPH assay, superoxide assay, tail immersion test, writhing test

 
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