alexa Abstract | Evaluation of Ibuprofen acid effect on oxidative stressed mice

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Ibuprofen ((RS)-2-(4-(2-methylpropyl) phenyl) propanoic acid) is a well-known non-steroidal anti-inflammatory drug (NSAIDs) widely used for the treatment of pain, fever and inflammation. This study designed to evaluate if dose of 30mg/kg of Ibuprofen has an antioxidant effect, relative to its analgesic, antipyretic and anti-inflammatory activities. Oxidative stress was induced by intraperetoneal injection of (100 mg/kg) peroxide hydrogen (H2O2), and then a comparative study is made concerning the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), gluthation reductase (GR), succinate deshydrogenase (SDH), and index of lipid peroxidation: thiobarbituriquc acid reactive substances (TBARS) determined lipid peroxidation in mice treated with H2O2 accompanied by Ibuprofen; compared to the group treated by L-ascorbic acid + H2O2, These results suggest that Ibuprofen may exert protective effects against oxidative stress damages.

To read the full article Peer-reviewed Article PDF image

Author(s): Benkhassi Zoubair Lahlou Fatima Azzahra Hmimid Fouzia Loutfi Mohammed Benaji Brahim and Bourhim Noureddine

Keywords

Ibuprofen, oxidative stress, antioxidant, anti-inflammatory, peroxide hydrogen (H2O2)., Ibuprofen

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us