alexa Abstract | Evaluation of iron chelating potential of methanolic extract of seeds of Celastrus paniculatus on iron intoxicated rats

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The seeds of Celastruspaniculatuswere collected and pulverized to fine powder and the powder was extracted by Soxhlet (continuous Hot Extraction) apparatus using methanol as solvent. In-vitro studies were carried out using various reagents like Ferrous Sulphate, Potassium thiocynate, Ferrozine, Desferrioxamine, purified water and methanolic extract of crude drug. The % iron-inhibition of standard and test drugs were measured. Animal studies were done using Iron intoxicated rats and Albino Wistar rats were subjected for iron dextrose injection (i. p.) six times in 21 days to all the groups (except normal control) and after treatment duration, Serum iron level, SGOT, SGPT, CKMB & Creatinine levels were measured. The iron chelating activity of Celastruspaniculatus was confirmed by in-vitro evaluation. There was significant decrease in serum iron levels in test group as compared to disease control group animals. The organo-protective effects on liver, heart and kidney was confirmed by reduction in various bio-markers like SGPT, SGOT, Creatinine and CKMB levels as compared to iron overloaded rats. The results of the study has shown that the methanolic extract of Celastruspaniculatus have significant iron chelating activity. It also has beneficial effects on hematological parameters and organo-protective effects were observed during study. So it can be useful in the management of iron overload disorders like thalassemia and hemochromatosis like conditions.

To read the full article Peer-reviewed Article PDF image

Author(s): Yash J Nakhva Rashmi C Anandpara Bhakti N Sojitra and Tejas H Ganatra

Keywords

Celastruspaniculatus, iron-chelation, phenolic content, iron dextran induced iron-intoxication.

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords