alexa Abstract | Evaluation Of Liposomal Clobetasol Propionate Topical Formulation For Intra-Dermal Delivery

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access


Hydroxy propyl methyl cellulose (HPMC) K4M gels containing free (HCF), liposome encapsulated clobetasol propionate (HCL) and physical mixture of the drug and lipids (HCP) were prepared and subjected to in vitro drug diffusion studies using rat skin to determine diffusion parameters. Data obtained were analyzed to calculate the amount of the drug in the skin (Qm) and the quantity of the drug in the recipient fluid (Csf) and its ratio (Qm/Csf). In vivo skin blanching assay of these formulations in human volunteers showed low blanching scores for liposomal gel formulations indicating low absorption of the liposomal drug in to the blood stream resulting in it's accumulation in the skin. Out of all the formulations tested, liposomal gel prepared with drug, phosphatidyl choline and cholesterol in the ratio of 2:4:1 showed highest Qm/Csf ratio and minimum blanching score.

To read the full article Peer-reviewed Article PDF image

Author(s): Gita Rao R S R Murthy

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version