alexa Abstract | Evaluation of thalidomide against indomethacin-induced small intestinal damage and systemic toxicity in rats

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Clinical use of indomethacin although efficacious in suppressing pain, fever and inflammation is frequently associated with deleterious effects on gastrointestinal, hematological and renal systems that limit its therapeutic use. This study examined in rats whether thalidomide, a known antiinflammatory agent with TNF-α inhibitory, immunomodulatory and anti-angiogenic properties could ameliorate indomethacin-induced toxicity that includes lethality, hematological and biochemical changes in blood, as well as the small intestinal damage. Wistar male rats in groups were treated orally with indomethacin (5, 10, and 20 mg/kg), thalidomide (100 and 200 mg/kg, either alone or in combination with indomethacin 5 mg/kg) once daily during 5 days. Lethality was assessed during this period and on day-5 blood samples were collected to examine the hematological and biochemical changes. The animals were then sacrificed and the small intestine removed for histological analysis. Results demonstrated that treatment with thalidomide did not improve the survival rate of indomethacin-treated rats. However, indomethacin-associated leucopenia, decrease in red blood cells, hemoglobin, and hematocrit as well as the elevation in plasma fibrinogen, serum AST and ALP, small intestinal lesion score, and the peritoneal liquid myeloperoxidase level were significantly suppressed by thalidomide treatment. In conclusion, the study suggests that thalidomide has the potential of ameliorating the toxic effects of indomethacin to a large extent, possibly by virtue of its anti-inflammatory properties.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Silva MA Rao VS Souza CM Neves JCS Menezes DB Santos FA Andrade GM


Indomethacin toxicity, thalidomide, plasma fibrinogen, small intestinal damage

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version