alexa Abstract | Evaluation of the anti-ulcer activities of Morus alba extracts in experimen-tally-induced gastric ulcer in rats.

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


This study was aimed to elucidate the anti-ulcerogenic effects of Morus alba ethanolic ex-tracts on ethanol induced gastric mucosal injury in animals. Four groups of adult male Sprague Dawley rats were included in the study. 10% Tween 80 was given orally to Group 1 rats as a negative control group. Group 2 and 3 animals received alcoholic ex-tract of Morus alba orally at 250 mg/kg and 500 mg/kg doses, respectively. Omeprazole (20 mg/kg body weight) were given orally to Group 4 rats as a positive control. 60 min-utes after their pretreatment, all rats were administered with 5 ml/kg absolute ethanol orally. One hour later, all animals were sacrificed. Grossly, Group 1 animals showed sever mucosal injury of gastric mucosa. However, a statistically significant reduction of gastric mucosal damage (p<0.05) was seen in animals pretreated with either plant ex-tracts (250 mg/kg or 500 mg/kg body weight) or Omeprazole compared to negative con-trol animals. Rats pretreated with 500mg/kg plant extract or omeprazole have signifi-cantly (p<0.05) protected gastric mucosa compared to animals pretreated with 250mg/kg plant extract. Microscopically, animals (Group 1) pretreated with 10% Tween 80 and administered absolute alcohol showed severe gastric mucosal damages, submucosal edema, and leucocytes infiltration. Animals pretreated with plant extracts or omeprazole showed marked reduction of gastric mucosal damage, reduction of edema and leucocytes infiltration of the submucosal layer. These results indicate that M. alba extract exhibits significant anti-ulcerogenic activity in rats.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Mahmood Ameen Abdulla Hapipah Mohd Ali Khaled AbdulAziz Ahmed Suzita Mohd Noor Salmah Ismail


Mourus alba, anti-ulcer, omeprazole, histology

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version