alexa Abstract | Evaluation of the Interaction of Aluminium Metal with Glutathione in Human Blood Components

Biomedical Research
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Abstract

Aluminium metal has important role in the field of medical sciences, but it has been found in various studies that Aluminium can cause numerous toxic effects. Studies have proven the strong affinity of the metalloelements for the sulfhydryl group (SH), present in reduced glutathione (GSH) and other biological molecules. In this context, the study about the possible interaction of Aluminium metal with glutathione in blood components was of interest, as an indication about the extent of Aluminium toxicity and the role of glutathione in the conjugation and detoxification of the metalloelement Aluminium metal. The concentration and time dependent effect of Aluminium metal on the level of GSH in plasma and Cytosolic Fraction in blood was investigated, following Ellman’s method. It was found that Aluminium metal causes a decrease in the GSH level, which is more pronounced with increasing concentration of Aluminium metal and with time incubation as well. The observed effect GSH concentration may be presumably due to production of oxidized glutathione (GSSG) or then due to Aluminium-Glutathione (GS-Al) conjugate formation

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Author(s): Haroon Khan M Farid Khan Barkat Ali Khan Ghulam Razaque Naheed Haque Basira Akhter Bakht Zareen

Keywords

Aluminium, Glutathione (GSH), Red Blood Cell (Cytosolic Fraction), Ellman’s method, 5, 5-Dithiobis, 2- Nitrobenzoic Acid (DTNB)

 
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