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Research Article Open Access
Objectives: To determine clinical and histopathological efficacy of Melia azedarach in healing of surgical skin wound.
Methods: Incisions of 10 -12 cm length created bilaterally in the thigh, flank and neck in (6) donkeys, 4 – 5 years old, 150 kg body weight. Melia azedarach ointment (10%) applied on wounds daily for 14 days. Biopsies from wounds for histopathology taken on day 5, 10 and 15 respectively.
Results: Histopathological sections at 5th day for non-infected wounds treated with melia azedarach revealed PMNs infiltration and fibrin exudates. Acute inflammatory cell infiltration, necrosis of the epidermis as well as sloughing were detected in infected wounds treated with Melia azedarach. in10th day, in treating non infected wounds a fibrous connective tissue proliferation, formation of new blood vessels and collagen bundle formation were noticed.
Infected wounds treated with melia azedarach, inflammatory reaction extend from epidermal, dermal to the muscular layer noticed. In nontreated non-infected wounds, replacement with fibrous connective tissue noticed. At 15th day, in treating non infected wounds, regeneration of sweat and sebaceous glands, formation of smooth muscle fibers, mature connective tissue replacement, many newly formed blood vessels noticed. In treated infected wounds, inflammatory cell infiltration in subcutaneous tissue, fibrous connective tissue proliferation noticed. In non-treated non-infected wounds, slight inflammatory reaction, noticed.The wounds clinically healed on day 15, and it was better in both wounds in thigh regions, followed by that on flank regions.
Conclusion: Melia azedarach has an Ã¯Â»Â¿ slight anti inflammatory reactionÃ¯Â»Â¿ and antibacterial activity and used effectively in treatment of infected wounds, which completely heal in 15 days.
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Author(s): AlKhafaji Nazar Falah H Khalaf Ahmed H ALZuhairi and Ali Ibrahim Ali AlEzzy
Melia azedarach, Wound, Histopathology., Phytomedicine, Therapeutics