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Original Articles Open Access
Diabetes mellitus is characterized by impaired endothelial cell production of the vasodilator and anti platelet adhesion factor nitric oxide (NO) .This study aimed to evaluate the role of exogenous L-arginine in diabetic rats in context of regulation of Asymmetrical Dimethylarginine (ADMA) and NO levels. Seventy five male albino rats were used in this study and divided into five groups ; Group I (Control group): healthy rats received a vehicle , Group II (L-arginine group): healthy rats received L-arginine (10 mM /Kg b.w./day ) orally for eight weeks, Group III (Diabetic group): diabetic rats received a vehicle, Group IV (Treated group): diabetic rats received L-arginine (10 mM /Kg b.w./day )orally for eight weeks, Group V (Prophylactic group): healthy rats received L-arginine (10 mM /Kg b.w./day ) orally before( two weeks ) and after ( eight weeks) induction of diabetes. Fasting blood sugar, insulin, blood urea, serum arginase and nitric oxide were determined. ADMA was determined by HPLC; separation was achieved on reversed phase column (150 X 4.6 mm C18).Mobile phase was eluted by gradient method; flow-rate was 1.0 ml/min. The wavelengths of fluorescence detector were set at 338 and 425 nm. In diabetic rats, serum ADMA was significantly increased along with the reduction of NO; however, L-arginine supplementation significantly decreased serum ADMA and increased NO in both prophylactic and treated groups. In conclusion, supplementation of L-arginine is a potentially novel mean to prevent diabetes-associated endothelial dysfunction through the reduction of asymmetrical dimethylarginine and the elevation of nitric oxide.
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Author(s): Ehsan Badawy Dina Abo ElMatty Hanaa Wafay Hoda Megahed Omnia Aly and Jihan Hussein
diabetes mellitus, endothelial dysfunction, L-arginine, ADMA, nitric oxide., L-Arginine