700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Original Articles Open Access
A novel and stability indicating, experimental design assisted liquid chromatographic method developed for the estimation of related substances of bromfenac sodium sesquihydrate. Stability indication of method established by forced degradation study. The chromatographic separation was attained with Kromosil C18,125 x 4.0mm, 5μm using gradient elution using mobile phase-A consists of a mixture of pH 4.8 ammonium acetate buffer and the mobile phase-B consists a mixture of methanol: Acetonitrile (500:500 v/v), respectively. Column temperature maintained at 30Ã¢ÂÂÃÂ¯ C with wavelength detection at 265nm.The develop method is validated as per International Conference on Harmonization (ICH) norms. Central composite experimental design (CCD) was employed to check the robustness of the method.
To read the full article Peer-reviewed Article PDF
Author(s): Vishnu Vardhana Rao G V Srinivasa Rao and K Ramakrishna
Bromfenac sodium, Liquid Chromatography , Validation, International Conference on Harmonization (ICH), Central composite design (CCD)., liquid chromatographic