alexa Abstract | Experimental study on promoting the regeneration of rat sciatic nerve using slow-release FK506-eluting peripheral nerve stent

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Design and construction of biocompatible tissue-engineered stents for long segment peripheral nerve regeneration has become a significant research topic. However, in the early of damaged, the immigration and aggregation of inflammatory cells and factors can induce a secondary nerve injury and peroxide damage to the injured nerves, which in turn can result in severe neuronal apoptosis. The use of immunosuppressant in the injury site can reduce the inflammatory reactions and secondary injury, and build a conducive microenvironment for nerve regeneration. In this study, we prepared tissue-engineering peripheral nerve stent using FK506, where the release of fk506 into the periphery after microsphere degradation still needs to pass through the stent wall. Such double effect of slow-release significantly reduced the burst release and prolonged the full release to 17 days. In our rat model of repairing a 20 mm sciatic nerve defect, 3 months after the surgery, the SFI and electrophysiological testing results of the ipsilateral side in group 1(FK506+PLGA+Stent) showed no significant difference from those in the autologous nerve grafting group. Morphological results also indicated that in terms of either the number of regenerated axons or the degree of myelin maturity, the regeneration outcome in group 1 was close to that in autologous nerve grafting group and significantly superior over that in the group 2(Only Stent). The slow-release FK506-eluting stent introduced in this study is easy for clinical application and provides a new experimental evidence of promoting peripheral nerve regeneration with tissue-engineering methods.

To read the full article Peer-reviewed Article PDF image

Author(s): Tan Ding Huping Hao Chao Zhu JunJie Du and ZhuoJing Luo

Keywords

Peripheral nerve, Tissue engineering, Slow-releasing, Stent, FK506, slow-release

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_polit[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords