alexa Abstract | Exploring use of quality by design (QbD) principles for development of modified release omeprazole pellets

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The present study was aimed to develop modified rel ease pellet of Omeprazole (OMP) applying various to ols of Quality by Design (QbD). Sugar spheres were drug la yered, barrier coated, extended coated and enteric coated in a fluid bed coater to achieve drug release extension. Based on previous knowledge and initial experiment al data, failure mode and effect analysis (FMEA) method were further applied in the risk analysis for the param eters of pellets formulation. Central composite design (CCD ) was employed to optimize OMP pellets selecting in dependent variables (% TEC in ER coat, % Enteric coat, % Exte nded coat) and responses (% drug release at 2, 4 an d 8 hrs. Statistical analysis exhibited that the most signif icant factor affecting Y 1 was X 2 . Factor X3 had significant negative effect on drug release at 4 hrs and 8 hrs which can be mathematically proved by regression equation of Y 2 and Y 3 . Results of physicochemical characterization of OMP pellets revealed compendia compliance. Results of s hort term stability study indicated stable characteristics of developed formulation.

To read the full article Peer-reviewed Article PDF image

Author(s): Niyaz S Mansuri Punit B Parejiya and Moinuddin M Soniwala


Omeprazole, Quality by Design, Risk assessment, Pellets, QbD, omeprazole

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version