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Inflammation is believed to play a crucial role in the onset and maintenance of migraine. Other key players in migraine are calcitonin gene-related peptide (CGRP) and its receptor components receptor activity modifying protein 1 (RAMP1) and calcitonin like receptor (CLR). In this study we provoked an inflammatory response in rat trigeminal ganglia following tissue culture. We show the bradykinin 1 receptor is immunohistochemically localized to the neuron nuclei in fresh ganglia and after tissue culture the localization has shifted to solely in the cytoplasm of some of the neurons. We also found that CGRP aggregated into distinct vesicles/granules upon tissue culture.
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Author(s): Kim A Kristiansen and Lars Edvinsson
Calcitonin gene-related peptide, Cytokines, Inflammation, Migraine, Trigeminal ganglia