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A sensitive spectrophotometric method has been developed for determining orphenadrine and diphenyldramine hydrochlorides from its pharmaceutical formulation based on solvent extraction into chloroform of the complexes formed with bromocresol green, bromophenol blue and methyl orange. Complex formation and extraction was complete and quantitative at pH 4. Direct determinations in capsule and tablet preparations were carried out satisfactorily and the average recovery was 100Â±1.0%.
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Author(s): P Nagaraja K C Srinivasa Murthy