alexa Abstract | Fabrication and characterization of chitosan-carbopol-71G polyelectrolyte complex-based mucoadhesive pellets of miconazole nitrate for vaginal candidiasis

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

Various approaches have been used in the past to overcome the problems associated with the delivery of antifungal drugs, for effective treatment of vaginal candidiasis. In the present investigation, mucoadhesive polyelectrolyte complex pellets (MPECP) loaded with Miconazole nitrate (MN) were prepared using chitosan/carbopol-71G interpolymer complex (IPC) by Fluid Bed Process (FBP) method. IPC was prepared by precipitation method, followed by characterization with Fourier transform infrared spectroscopy (FT-IR) and Differential scanning calorimeter (DSC). The prepared MPECP were tested for physicochemical properties, in vitro drug release behavior, swelling studies and mucoadhesive strength. The possibility of chemical interaction between drug and excipients was ruled out in the prepared pellets as confirmed by FT-IR and DSC studies. SEM photomicrographs showed that pellets had rough surface and were spherical. The dissolution behavior of MN from MPECP into the simulated vaginal fluid (SVF) pH 4.2 was controlled and followed non-fickian release mechanism. Moreover, in vitro mucoadhesive study confirmed that complex MP3 showed pH independent controlled releases of MN without an initial burst release, with highest mucoadhesive property and satisfactory residence in vaginal cavity (8h) of rat. The adherence of swelled pellets (MP3), for over 8 hrs, to the vaginal mucous membrane was confirmed by in vivo X-ray studies. The results showed no significant change in the pellet properties and drug content. Thus, the formulated MPECP seems to be a potential candidate for controlled release of MN in vaginal pH with optimum swelling behavior and zero order release.

To read the full article Peer-reviewed Article PDF image

Author(s): Devegowda Vishakante Gowda Atul Srivastava Gritta Sebastian and Prerana M

Keywords

Mucoadhesive polyelectrolyte complex pellets, Fluid Bed Process, Miconazole nitrate, In vitro mucoadhesive test, In vivo X-ray studies, candidiasis

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords