alexa Abstract | Fabrication and comparative bioavailability of modified gum microspheres loaded with disopyramide phosphate

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


The present study aims to develop a controlled release formulation of Disopyramide Phosphate (DSP) loaded into natural and modified gum microspheres, using water-in-oil emulsification solvent evaporation technique utilizing wetting agent. Effect of different process variables such as drug and gums ratio (1:1: 0.75 % w/v), stirring speed and time ( 1800 rpm & 210 min ), addition of surfactant (0.5 % w/v), effect of oily phase ( 200 ml), temperature of the emulsified phase (800 C), effect of cross-linker (0.5 % w/v) and effect of encapsulating agent (1.2 % w/v) on drug loading during the preparation of microspheres were optimized to produce microspheres. Sieve analysis data indicated that the prepared microspheres were in the range of 106 to500 μm. Prepared microspheres were spherical in shape as shown by SEM photomicrographs. Encapsulated drug in the prepared formulations was stable as confirmed by FTIR & DSC studies. A single dose randomized two period cross over study was conducted to compare the pharmacokinetics and bioavailability of test formulation DXML1 (product B –150 mg of DP loaded in MLBG) with standard formulation (Product A - Norpace® CR- 150 mg capsule). The observed mean values Tmax, Cmax, AUC0 -∞, Ka, t 1/2 and Kel for products A & B does not show any significant statistical difference. From the dissolution point and in vivo bio availability for products A & B could be considered bio equivalent. The drug release performance was greatly affected by the materials used in the microsphere preparation which allows maximum absorption in the intestine

To read the full article Peer-reviewed Article PDF image

Author(s): Anjana John Zeinul Hukuman N H and D V Gowda


Gum microspheres, Controlled release, Disopyramide phosphate, Release kinetics, bio availability, bioavailability

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version