alexa Abstract | Fabrication and evaluation of bi-layer tablet containing conventional paracetamol and modified release diclofenac sodium

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


The objectives of present investigation were to achieve immediate release of paracetamol and tailored release of diclofenac sodium from bi-layer tablets. A 2 3 full factorial design was adopted using the amount of polyethylene glycol, microcrystalline cellulose and crospovidone as independent variables for fabricating paracetamol tablets. Diclofenac sodium tablets were prepared using hydroxypropyl methylcellulose as a matrixing agent. The results of analysis of variance showed that the friability of paracetamol was distinctly influenced by the formulation variables. The in vitro drug release behaviour of diclofenac tablets was compared with a marketed formulation. The optimized formulations of paracetamol and diclofenac sodium were used for manufacturing of bi-layer tablets. The bi-layer tablets showed immediate release of paracetamol and modified release of diclofenac.

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Author(s): MC Gohel RK Parikh SA Nagori BA Jethwa


Bi-layer tablet, diclofenac sodium, factorial design, paracetamol

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