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Research Paper Open Access
Atenolol was formulated as fast disintegrating tablet using three superdisintegrants, croscarmellose sodium (Ac-Di-Sol), crospovidone (Polyplasdone XL) and sodium starch glycolate (Explotab). Thirteen formulations were prepared and all had the same amount of ingredients except, the superdisintegrant level. All the superdisintegrants were used at different concentration levels to assess their efficiency and critical concentration level. Physical characteristics, in vitro release characteristics, moisture uptake and stability profile of various formulations were evaluated. Moisture uptake by formulations was studied to reveal any relationship between moisture uptake and disintegration and/or dissolution efficiency. Ac-Di-Sol proved to be the best among the three and showed satisfactory results at 3 kg/cm2 hardness. Formulations were found stable in release profile after 30 d stability studies at room temperature.
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Author(s): A A Shirwaikar A Ramesh