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Fibrinogen-like protein 2 (Fgl2)/fibroleukin has recently been identified as a new member of fibrinogen-related protein superfamily, with the serine protease activity. Fgl2 functions as a novel immune coagulant with the ability to generate thrombin directly,and may be involved in angiogenesis. Cells proliferation and cell migration are critical steps in angiogenesis. In the present study, we investigated the expression of hFgl2 mRNA after Fgl2 RNAi transfection in myocardical microvascular endothelial cell,we found that Fgl2 mRNA expression decreased significantly.Results also showed that the proliferation and migration of myocardical microvascular endothelial cell increased significantly after Fgl2 RNAi transfection. The decreased Fgl2 mRNA levels,result in increased Tie2, Ang1, and Ang2 gene expression in myocardical microvascular endothelial cell.This study indicated that Fgl2 Gene silencing activates angiopoietin/Tie system and induces Myocardial Microvascular Endothelial Cells proliferation and cell migration.
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Author(s): Zhenzhong Zheng Liang WangYoupin Wu Huifang Wang Dengpeng Gao Yuya Fa Yunfeng Wei Menghong Wang Zeqi ZhengJintian Peng
Fibrinogen-like protein 2, angiopoietin/Tie system, cell proliferation, cell migration