alexa Abstract | Fixed dose combinations in the treatment of tuberculosis.

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access

Abstract

Tuberculosis is a complex socio-economic problem that impedes human development. Tuberculosis exerts a toll of eight million new sufferers and two million deaths every year. Around one third of world population harbors Mycobacterium tuberculosis that is sensitive to rifampicin, isoniazid, pyrazinamide and ethambutol. As tuberculosis is contagious, it infects many others thereby necessitating early diagnosis and treatment. A standard 6 months treatment regimen formulated by World Health Organization (WHO), in its operational point of view is a complex procedure leading to treatment failure and resugence of drug resistant strains. To increase the patient compliance, in its recently revised Tuberculosis Treatment Guidelines for National Tuberculosis Programs, WHO encourages the use of Fixed Dose Combination (FDC) tablets, which assures ingestion of all the components of tuberculosis treatment regimen. However, the major quality issue associated with FDCs is assuring the bioavailability of rifampicin. If not carefully manufactured, bioavailability of rifampicin is negatively affected which could directly lead to poor treatment outcome and may lead to drug resistance. In the light of above scenario, this review mainly focuses the potential advantages of FDC formulations with special emphasis on quality of FDC preparation to be used for tuberculosis control.



Author(s): R Panchagnula S Agrawal CL Kaul

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords