alexa Abstract | Fluticasone propionate liposomes for pulmonary delivery

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract Open Access

Abstract

The objective of the present study was to entrap fluticasone propionate in liposomes and study in vitro lung deposition of both liposomal dispersion and dry powder inhalation using twin stage impinger and Anderson cascade impactor. Liposomes were prepared by lipid film hydration method and characterized for size, shape, morphology, entrapment efficiency and in vitro lung deposition. The spray dried liposomes were further characterized for various physicochemical properties such as physical appearance, density, flow properties, drug content and in vitro pulmonary deposition. Fine particle fraction was also determined. Liposomal dispersion of fluticasone propionate was successfully prepared with more than 90% entrapment. Spray dried liposomes had mean size of 3-4 µ and a fine powder fraction of 9-10 %. Inclusion of antistatic agents such as leucine and magnesium stearate did not improve the aerosolisation behaviour of dry inhalation powder in this study.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): NM Nirale RD Vidhate MS Nagarsenker

Keywords

Dry powder inhaler, fluticasone propionate, antistatic agents

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords