alexa Abstract | Folate and Homocysteine metabolism in Indian children with Down syndrome.

Current Pediatric Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Down syndrome (DS) individuals present abnormalities in folate-homocysteine metabolism that is attributed to the additional copy of the Cystathionine β-synthase (CβS) gene located on chromosome 21. Therefore, the aim of the study was to estimate the plasma levels of folate and homocysteine (Hcy) and compare it with age and sex matched healthy controls. The results showed a significant decrease in Hcy levels in DS. Moreover, cases affected with congenital heart defects presented statistically significant increase in Hcy levels but the same was not observed with folate. Decreased levels of folic acid and homocysteine were observed in cases with neural tube defects but found insignificant. Decreased Hcy concentration leads to functional folate deficiency contributing to the metabolic pathology in DS. The study recommends folinic acid supplementation for DS individuals.

To read the full article Peer-reviewed Article PDF image

Author(s): Nandha Kumar S Bahubali Gane Ramachandra Rao K Vishnu Bhat B

Keywords

Down syndrome, Oxidative stress, DNA damage, DNA hypomethylation, Folic acid, Homocysteine, Cystathionine β-synthase, MTHFR, Folinic acid, Congenital heart defects, Neural tube defects

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords