alexa Abstract | Formation of rare earth metal complexes with Zonisamide in aqueous medium

Journal of Chemical and Pharmaceutical Research
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The stability constant of Zonisamide with trivalent rare earth metal ions Ce3+, Pr3+, Nd3+, Pm3+ and Gd3+ using a pH metric titration technique in aqueous medium at 25°C temperature and at an ionic strength of 0.2M NaClO4 were studied. The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine metal-ligand stability constant (logK) values. The trend in the formation constants follows the order: Pr3+ < Ce3+ < Nd3+ < Pm3+ < Gd3+

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Author(s): S V Thakur Jameel Pathan Farooque Bashir Ansari and D D Kayande


Zonisamide drug, Stability constant, rare earth metal ions, pH meter etc, metal complexes

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