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Research Paper Open Access
Î²-Cyclodextrin complexes of meloxicam were prepared by solvent evaporation technique in different ratios to enhance the solubility of the drug. The complex was characterized by infrared spectroscopy and differential scanning calorimetry studies. There was no interaction between drug and carrier. Based on physical characters and in vitro drug release pattern, 1:3 drug-carrier ratio was selected as ideal batch for suppositories. A water-soluble base, polyethylene glycol, was selected as ideal base for the preparation of suppositories. The suppositories were prepared by moulding technique. The ideal batch of solid dispersion was incorporated into suppository base. The prepared suppositories were characterized for hardness, melting point, disintegration time and drug content. All these properties were found to be ideal. The in vitro drug release pattern was determined by rotating dialysis bag method. The in vitro release of. meloxicam from its solid dispersion incorporated suppositories was significantly improved when compared to the intact bulk drug incorporated suppositories.
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Author(s): K Gowthamarajan T Giriraj Kulkarni G Venkateswaran M K Samanta B Suresh