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Research Article Open Access
Floating matrix tablets of Alfuzosin hydrochloride were developed to prolong gastric residence time. Alfuzosin hydrochloride was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by direct compression and melt granulation technique, using polymers such as hydroxy propyl methyl cellulose K15M, sodium carboxy methyl cellulose, compritol 888 ATO and either alone or in combination, and other standard excipients. Tablets were evaluated for physical characteristics hardness, % friability, floating capacity, weight variation, content uniformity, in-vitro release characteristics for 12 hours and in-vivo gastic retention time. In-vitro release mechanism was evaluated by linear regression analysis. The calculated regression coefficients value of higuchi and koresemayer (0.998, n value 0.520) for optimized formulation F2 and the drug release mechanism was found to be non-ficikian diffusion. No drug-polymer interaction was observed by Fourier Transform Infrared Spectra Analysis. In-vivo studies showed that the tablets retained in stomach for 6hours. It was concluded that, HPMC K15M alone retarded the drug release for highly water soluble drug (Alfuzosin hydrochloride) for a period of 12 hours.
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Author(s): Anitha Kakkerle Sandeep Gummudavelly Raju Jukanti Veerareddy Prabhakar Reddy
Alfuzosin hydrochloride, Floating, X-ray radiographic studies, HPMC, compritol 888ATO