alexa Abstract | Formulation and evaluation of certain hypoglycemic agents

Journal of Chemical and Pharmaceutical Research
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Abstract

The aim of this investigation was to prepare fast dissolving tablets of ( glibenclamide and glimepiride each alone) using solid dispersion and various concentrations of superdisintegrant agents like Ac-Di-Sol , crospovidone and sodium starch glycolate by direct compression method. Nine formulations having superdisintegrants at different concentration levels were prepared. These tablets were evaluated for drug content , weight variation, friability, hardness, and invitro disintegration time . Among the formulations tablets choose F6 and F7 from glibenclamide formulations and F3, F6 from glimepiride formulations with excellent in-vitro disintegration time as compere to other formulations. For stability study tests for 12 weeks at humidity 75 % and temperature ( 40 , 50 , and 60 °C ). All formulations are stable at 40 °CIt was concluded that solid dispersion technique is a useful method for preparing fast dissolving tablets by direct compression method. Direct compression is the easiest method to manufacture fast dissolving tablets (FDTs). The great advantage of direct compression is its low manufacturing cost. It uses conventional equipment, commonly available excipients and a limited number of processing steps .

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Author(s): Ahmed Alsabati Mahmoud Alburyhi and Fesal AlDgshe

Keywords

glibenclamide, glimepiride, fast dissolving tablets, Ac-Di-Sol, crospovidone, sodium starch glycolate, hypoglycemic agents

 
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