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Research Paper Open Access
Self-crosslinked microcapsules of chlorpromazine hydrochloride were prepared by coacervation phase separation technique followed by extensive dehydration at elevated temperature and pressure with gelatin. Self-crosslinked microcapsules showed about 99% of drug release within 12h, followed a first order kinetics. The in vivo studies revealed the maintenance of long duration of therapeutic effective plasma concentration without reaching the toxic level. The minimum catatonic scores in albino rats indicate that the microcapsules might even have reduced the drug-induced extrapyramidal syndrome.
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Author(s): M K Samanta S Tamilvanan K Babu B Suresh