700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
The present endeavor was directed towards fabrication of the novel drug delivery system of naproxen. The fast disintegrating core tablets of Naproxen were prepared by direct compression technique. These tablets were coated with Guar gum& Xanthan gum (Polysaccharide polymer). . The tablets were evaluated for hardness, friability, weight variation, swelling index, drug content, in vitro release studies. In vitro drug release studies were carried out in presence and absence of rat cecal contents and revealed that Guar gum & Xanthan gum, when used as compression coating, protected the drug from being released in the upper parts of the gastro intestinal tract (GIT). Completely protected the drug from being released in the upper parts of the GIT, and released the drug only in the colon by bacterial degradation of gums. It was found that the polysaccharide polymer Guar gum & Xanthan gum completely protect the drug release in the upper digestive tract and exhibited different release profiles in presence and absence of rat cecal contents. Hence, Guar gum & Xanthan gum can be used for targeting the drug to the colon for controlling the release of drugs.
To read the full article Peer-reviewed Article PDF
Author(s): Sumit Kumar Anurag Bhargava
Naproxen, Colon, Compress coat, Guar gum, Xanthun gum