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Original Articles Open Access
The purpose of the present study was to formulate the oral controlled release Trimtazidine di hydrochloride tablets by using Polysaccharide B-1459 (14-38%) as rate controlling polymer. The tablets were prepared by direct compression method and coated by the film coating polymers. The powder mixtures were evaluated for angle of repose, loose bulk density, tapped bulk density and compressibility index, shows satisfactory results. All the ingredients were lubricated and compressed using 8mm circular shaped deep concave punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, thickness, friability, hardness and In-vitro dissolution studies. Drug content in formulation was determined by HPLC Method . All the formulation showed compliance with Pharmacopoeial standards. The in vitro release study of matrix tablets were carried out in 0.1N Hydrochloric acid with pH 1.2 for 10 hours. The prepared matrix tablets were shown 98.00%, 99.00%, 100.00%, 104.00%, 92.00% and 100.00% release over a period of 10 hours. Formulation F1, F2 and F3 failed to sustain release beyond 10 hours. Among all the formulation, F6 shows 100.00% release at the end of 10 hours. It was observed that the amount of polymer influences the drug release. In vitro release study results revealed that the release of drug was retarded with the proportional increase of the polymer concentration. It was indicated that the using a hydrophilic non-cellulosic polymer in an appropriate combination in tablet could control the rate of drug release.
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Author(s): Raj KumarMarikanti Kiran JoshiPVidya SagarCH Venkateswara reddyBKirankumarANagarajuI Srinivasa RaoPand JRavi kiran
Trimtazidine dihydrochloride, Matrix tablets, direct compression, Controlled release.