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Research Article Open Access
The purpose of the present study was to develop a gastric floating drug delivery system (GFDDS) containing Levofloxacin against the H.pylori infection using gas-forming agents, like sodium bicarbonate, citric acid and hydrocolloids, like Hydroxypropyl ethylcellulose (HPMC) and Carbopol 974P. The prepared tablets were evaluated in terms of their pre compression parameters, physical characteristics, in vitro release, buoyancy, floating lag time (FLT), total floating time (TFT) and swelling index. The formulations were optimized for the different viscosity grades of HPMC, Carbopol 974P and its concentrations and combinations. Stability study was also performed after storage at 40°C/75% RH for three months. All the formulations showed good floating lag time i.e. less than 3 mins. The batch containing combination of HPMC K4M, HPMC K100M and Carbopol 974P (i.e. L12) showed total floating lag time more than 24 hrs. The batch L12 showed the highest swelling index among all the prepared batches (i.e. 95%). The batch L12 was chosen as the optimized batch since it was also stable for three months during stability study.
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Author(s): Shreeraj H Shaha Jayvadan K Patelb Nirav V Patel
gastric floating drug delivery system, total floating time, HPMC, Carbopol 974P, stability study