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Now days tablet dosage forms are supplanted by new drug delivery system because of problems like hepatic metabolism, GI toxicity and enzymatic degradation which leads to non-compliance and ineffective therapy. These problems can be overcome by formulating the drug into fast dissolving buccal patches for oromucosal absorption with fast onset of action and improved bioavailability. In present work the fast dissolving buccal patches of Olmesartan medoxomil was prepared by solvent casting method using HPMC E5, HPMC 3cps and HPMC K100 as a film formers and PEG 400 as plasticizer. The prepared patches were evaluated for weight, thickness, folding endurance, surface pH, disintegration time, in-vitro drug release and stability studies on optimized formulation. The thickness of the all patches was found in the range of 0.22 to 0.30 mm. The disintegration time was found up to 60 sec. and the folding endurance was up to 200. The in-vitro drug release was found to be up to 100% within 2 minutes. Thus the fast dissolving buccal patch of Olmesartan medoxomil was successfully formulated to achieve a safe, rapid and effective dosage form with enhanced drug dissolution and rapid antihypertensive therapy.
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Author(s): Gorakh J Dhumal Durgacharan A Bhagwat John I Disouza
Fast dissolving buccal patch, HPMC, Solvent casting method, invitro drug release.